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New Study Demonstrates Effectiveness of Renuva® Allograft Adipose Matrix in Improving Reconstructive and Dermatologic Procedures ​


New peer-reviewed clinical study further bolsters evidence that the implantation of allograft adipose matrix leads to safe, sustained volume retention in human tissue

Edison, N.J. (May 2, 2019) – A clinical study released today by MTF Biologics provides more evidence of the clinical utility  of Renuva® Allograft Adipose Matrix in treating small-volume aesthetic soft tissue irregularities. Called Injectable Allograft Adipose Matrix Supports Adipogenic Tissue Remodeling in the Nude Mouse and Human, the peer-reviewed study demonstrated sustained volume retention post-injection of allograft adipose matrix into the dorsal wrist, adding further credence to pre-clinical studies that produced positive results.

“In recent decades, clinicians have increasingly used autologous fat grafting to treat individuals’ aesthetic defects,” said Marc Long, Ph.D., Vice President of Research and Development at MTF Biologics. “MTF Biologics devoted years of research and development to produce safe and effective ways to use donated allograft adipose matrix in the same way, thus eliminating the need for liposuction. We’re delighted by the positive results of this study as it further supports the benefits of adipose in plastic and reconstructive medicine and dermatology.”

The study also provides evidence that human allograft adipose matrix with retained endogenous proteins -- those that already exist in native adipose tissue -- is safe and effective in retaining volume when the matrix interacts with the host cells.

The latest study bolsters the findings of earlier pre-clinical analysis which determined that allograft adipose matrix is suitable for transplantation, acting physiologically like autologous fat and offering an off-the-shelf application without the need for liposuction. These pre-clinical and clinical studies include:

  • Current Use of Biological Scaffolds in Plastic Surgery: Takes a deep-dive into the current uses of scaffolds in plastic surgery, which includes skin replacement, breast reconstruction and abdominal wall repair. Reveals the shared responsibility of each scaffold, including adipose-derived, to perfectly replicate the host tissue, mimicking all of its biophysical and structural details, and supporting cell processes such as adhesion, replication, and growth.


  • Pre-Clinical Assessment of an Adipose-Derived Allograft Scaffold: Shows that allograft adipose matrix is remodeled by the host cells in the body and demonstrates clear signs of the formation of new blood vessels, cell recruitment and adipogenic differentiation. Further proves the potential for long-term volume retention of allograft adipose matrix in the human body.


  • Tissue Augmentation with Allograft Adipose Matrix For the Diabetic Foot in Remission: Suggests allograft adipose matrix injected in the high-risk diabetic foot can potentially reduce tissue stress surrounding post-ulcerative lesions and pressure points. This development may ultimately assist the clinician in extending the number of ulcer-free days for patients in diabetic foot remission.


  • Preclinical Optimization of a Shelf-Ready, Injectable, Human-Derived, Decellularized Allograft Adipose Matrix: Demonstrates that allograft adipose matrix contributes to preparation of the patient’s tissue before, or in combination with, autologous adipose tissue grafting by increasing vascularity and creating an adipogenic microenvironment.

Renuva® Allograft Adipose Matrix will be discussed at the Symposium for Cosmetic Advances and Laser Education (SCALE), May 9-11, 2019 in Nashville, TN. It also will be featured at the American Society for Aesthetic Plastic Surgery (ASAPS) Aesthetics Meeting, May 16-21, 2019 in New Orleans, LA.

For more information on Renuva® Allograft Adipose Matrix, visit:

About MTF Biologics

MTF Biologics, also known as the Musculoskeletal Transplant Foundation, is a nonprofit organization based in Edison, N.J. It is a consortium comprised of leading organ procurement organizations, tissue recovery organizations and academic medical institutions, and governed by a board of surgeons who are leading experts in tissue transplantation. As the world’s largest tissue bank, MTF Biologics saves and heals lives by honoring donated gifts, serving patients and advancing science. Since its inception in 1987, the organization has received tissue from more than 132,000 donors and distributed more than 8.6 million grafts for transplantation. Through its IIAM subsidiary, it has placed more than 58,000 non-transplantable organs for research. Through its Statline subsidiary, it has managed more than 11.3 million donor referrals. For more information, visit

Media Contact: Christian Lail, 615-610-0307,